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UC Irvine Institute for Clinical and Translational Science in collaboration with the Naval Hospital, Camp Pendletonare pleased to announce the

2013 ICTS/Camp Pendleton Collaborative Grant Award Recipients

The ICTS/Camp Pendleton Collaborative Grant was created by the ICTS and the Heroes@Home Program to encourage novel collaborations among clinical and basic science researchers from the UCI Institute of Clinical and Translational Science and the Naval Hospital at Camp Pendleton. This year’s awardees are:


Non-invasive hemodynamic stress assessment for detection and therapeutic monitoring of cerebral/muscular injury
Albert Cerussi, PhD, University of California, Irvine, Beckman Laser Institute,
Commander Todd J. May, DO, Sports Medicine, Naval Hospital, Camp Pendleton, CA
Joon You, Project Scientist, University of California, Irvine, Beckman Laser Institute

Given the high portability of our diffuse optical functional imaging technology platforms, longitudinal monitoring of TBI/PTSD/muscle injury countermeasures is our pilot goal. Functional imaging devices, designed to noninvasively probe both brain and muscle tissues, can be rapidly deployed at Camp Pendleton in primary care settings – no special clinic orresearch space is required. Brain and muscle tissues will be accessed using fiber-optic probes. Small perturbations, such as short breath holds, head tilts, limb occlusions, or exercise/strength tests can be used to generate hemodynamic stresses that can be measured non-invasively. In particular, longitudinal monitoring of cerebral/muscular tissue response to therapy will provide mechanistic insight into the disease/disorder process: then a forward predictive model to detect/screen these conditions can be developed. This is the long-term goal of the project. There are several protocols listed for the Clinical Investigation Program at the Naval Hospital Camp Pendleton that involve the treatment of TBI, PTSD, and physical performance that we could monitor with our approach.


Treatment of Tinnitus Using a Web-Based Sound and Cognitive Behavioral Therapy
 Hamid R. Djalilian, MD, University of California, Irvine, Department of Otolaryngology,
James Henry, PhD, Department of Otolaryngology, Veterans Affairs
Commander James Caviness, MD, Occupational Medicine, Naval Hospital, Camp Pendleton, CA

Sound therapy combined with cognitive behavioral therapy is the most successful method of treating tinnitus with ~90% efficacy. In the military, there is no established program for treating tinnitus. The VA has developed a comprehensive protocol on Progressive Tinnitus Management. This protocol, which combines sound therapy and cognitive behavioral therapy, has had significant success. However, this and other available treatment protocols have numerous drawbacks that limit their applicability in military or civilian settings. These drawbacks can be addressed in three categories:accessibility (currently treatment is only available at major tinnitus centers), cost ($2000-$5000/patient), and multiplerequired visits (3-10 visits). Considering the impact of tinnitus on the military and veteran populations, the need for a cost-effective, widely accessible, and effective treatment protocol for tinnitus is urgent. We propose innovative research to achieve the following two specific aims: (1) To develop a web-based cognitive behavioral therapy for tinnitus in themilitary tinnitus patients. (2) Develop educational material for the PTSD and stress-induced tinnitus patients.