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UCI MIND Seminar Series: Christian Lasagna-Reeves, PhD Dr. Lasagna-Reeves is currently the Associate Professor of Anatomy, Cell Biology, and Physiology, and serves as the Director of Neurodegenerative Research at Stark Neurosciences Research Institute, Indiana University School of Medicine. His postdoctoral work was conducted at Baylor College of Medicine under Dr. Huda Zoghbi. He earned his Ph.D. in Cellular Biology from the University of Texas Medical Branch and also holds a M.Sc. in Biological Sciences and a B.S. in Engineering in Biotechnology, both from the University of Chile. Dr. Lasagna-Reeves recently identified the presynaptic protein Bassoon (BSN) as an interactor of tau seeds isolated from a mouse model of tauopathy and AD patients. His results demonstrate how BSN downregulation decreases tau spreading and rescues behavioral impairment in a mouse model of tauopathy. His findings highlight the importance of identifying tau interactors, such as BSN, that could act as stabilizers of the tau seed, enhancing its propagation and toxicity. |
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UCI MIND Seminar Series: Celeste Karch, PhD Dr. Karch is an Associate Professor of Psychiatry at Washington University School of Medicine at St. Louis. She holds a PhD from the University of Florida (2009) and a BA from Kalamazoo College (2005). She has garnered several accolades in the field of Alzheimer’s research, including the Chan Zuckerberg Initiative Neurodegeneration Challenge Network Investigator Award in 2019. Her career is also distinguished by a variety of other awards, such as the Dominantly Inherited Alzheimer’s Disease Young Investigator Award in 2017 and her involvement as an NIH Early Career Reviewer in 2014. The goal of the Karch lab is to understand the molecular drivers of Alzheimer’s disease and frontotemporal dementia. To do this, Dr. Karch uses functional genomics alongside stem cell and mouse models. Here, she will show that rare variants in TREM2 and common variants in MS4A4A that modify risk for dementias shift the molecular state of microglia and impact lysosomal and lipid functions. |
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CHOC Research Day 2023 Topic: Transforming Challenges into Opportunities: Pediatric Mental Health Services Research |
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UCI Conte Center Seminar Series: Flavio Donato, PhD Topic: Memory dynamics through the divergent recruitment of developmentally-defined hippocampal traces |
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Physician Scientist Collective: Distinguished Speaker Series The Physician Scientist Collective Distinguished Speaker Series features speakers from diverse medical fields across national academic institutions who share their experiences and insights on physician scientist careers. |
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2023 Community Lecture Series Join us on Tuesday, November 7th at 7:00 PM for Dr. Leslie Thompson and Dr. Devon Pendlebury’s community lecture held in-person at Gross Hall Thorp Conference Center. Light refreshments provided. |
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The Great Debate! Is It the Food or the Fitness? Join us for “The Great Debate! Is It the Food or the Fitness? A Friendly Debate on How Best to Mitigate the Chronic Metabolic Disease Epidemic” – a CME and MOC-2 presentation. |
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UCI MIND Seminar Series: Timothy Chang, MD, PhD Dr. Chang holds a bachelor’s degree from Stanford University, as well as M.D. and Ph.D. degrees from the University of Wisconsin, Madison. He specialized in Neurology at UCLA, where he also completed a fellowship in Neurobehavior and Movement Disorders. Dr. Chang is an Assistant Professor of Neurology at UCLA with clinical expertise in Alzheimer’s disease and related dementias, including various movement disorders. His research focuses on computational analysis of large datasets to understand the genetic and clinical determinants of Alzheimer’s and aims to develop personalized therapies. Genetic risk models for dementia have been studied from longitudinal cohorts but have not been well investigated in real world data including electronic health records. Dr. Chang will present his work on identifying shared genetic risk between Alzheimer’s disease and epilepsy, and genetic risk modeling in understudied populations from real-world data. |
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UCI MIND Seminar Series: Sokol Todi, PhD Dr. Sokol V. Todi is Professor in the Departments of Pharmacology and Neurology at Wayne State University School of Medicine and the Chair of the Department of Pharmacology. Dr. Todi has been awarded Young Investigator in Spinocerebellar Ataxias (SCA) 2 times in a row by the National Ataxia Foundation and more recently with a Pioneer Award in SCAs. Dr. Todi’s laboratory investigates mechanisms of neurodegeneration and neuroprotection in age-dependent neurodegenerative diseases caused by misfolded proteins, with particular focus on polyglutamine disease proteins.This presentation will focus on the family of polyglutamine diseases of the nervous system, which comprises nine distinct members that include Huntington’s Disease and several Spinocerebellar Ataxias. The Todi lab has generated a unique series of isogenic Drosophila melanogaster transgenic lines that is being utilized to further understand mechanisms of polyglutamine toxicity and to uncover therapeutics for them. |
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Responsible Conduct of Research Workshop RCR is defined as the practice of scientific investigation with integrity. It involves the awareness and application of established professional norms and ethical principles in the performance of all activities related to scientific research. |
